Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
If you are in a great deal of pain and discomfort, your physician may recommend use of NSAIDs. I personally believe that medication is a short-term solution, and other steps must be taken to correct this problem.
Exercise
When a joint is injured, the knee begins to swell, which can hamper the movement of the knee and can cause the muscles to atrophy or weaken, placing more force on the joint at a time when it is least able to sustain it. Therefore, it is very important to get the joint moving as soon as possible and to keep the muscles strong. For articular cartilage problems such as arthritis or chondromalacia, I recommend a low-impact exercise program that strengthens the muscles without stressing the joint. Activities such as swimming, riding a stationary bicycle, or even using a cross-country ski machine could be beneficial. (If you use a stationary bicycle, set the seat in such a way so that you do not bend you knee more than 90 degrees, because it often causes discomfort.) If you are disciplined about exercising, you may work out on your own. However, if you exercise haphazardly, you may need to work out with a trainer or at an exercise rehabilitation center. In this world of medical cost containment, there will unquestionably be a cutback in rehabilitative services, so that patients will be required to exercise on their own.
“Washing Out” the Joint
Very often, a patient with an injured joint may have difficulty extending her leg and keeps the knee in a flexed position. This is often due to a protective spasm of the hamstrings, and gentle exercise may help return the leg to normal motion. However, a “locked” leg may also result from a torn or jagged piece of cartilage that is caught in the joint (either between the tibia and the femur or the patella and the femur) and is preventing full extension. If your doctor suspects that this is the case, he may arthroscope the knee to “wash out” the debris and smooth out the surface. Although this isn’t a permanent solution, many patients feel better.
Reattaching the Cartilage
If a big piece of articular cartilage with its underlying bone is ripped off in an injury, it may be possible to reattach it back into position using wires or absorbable pins. If indeed, there is a significant bone attached, the injury is an osteochondral fracture, and if there is a short interval (roughly 4 to 8 weeks) between injury and surgery, there is an excellent chance that the fracture will heal if pinned back into position. If the injury does not include a bone surface, the articular cartilage by itself cannot be reattached with any certainty of success. Instead, attention is directed to the bone to produce fibrocartilage, which, although biomechanically inferior to articular cartilage, will fill the defect.
It would be wonderful if there was a synthetic material that could be used to “paint” back missing areas of articular cartilage. Unfortunately, there is nothing comparable that is available now. Although investigation and experimentation is being done, today there are only three methods of replacing absent cartilage:
Procedures designed to stimulate or regenerate the growth of cartilage cells.
Bulk allografts (bone transplants).
Cartilage cell growth and subsequent transplantation.
Regeneration of Cartilage. Since the 1800s, scientists have dreamed of developing a way to get the body to regenerate articular cartilage, and although there have been some promising developments in this field, it is still highly experimental. In the body, cartilage is produced by special cells that, depending on their location, have the ability to produce either bone, fibrous tissue, or cartilage. We don’t know the precise triggers that “turn on” these cells and instruct them to produce cartilage. We do know, however, that injuring the bone can in many cases trigger the growth of cartilage. There are several ways that we do this, but basically they all involve making the bone bleed. In some cases, the surgeon will drill holes in the bone to stimulate these special cells to grow cartilage. Another procedure called abrasion arthroplasty involves a more aggressive procedure that causes more bleeding and hopefully produces more fibrocartilage. All of these procedures to stimulate fibrocartilage production can be done arthroscopically, but because the bone is actually involved, the procedures are associated with more discomfort than routine arthroscopy.
Bulk Allografts. Bulk allografts are pieces of bone and/or cartilage that are taken from a cadaver and put in the patient. For years, this procedure has been done in tumor patients. Unfortunately, many of these cancer patients also underwent chemotherapy and radiation treatments and thus were immunosuppressed, which made them prone to infection. As a result, there was a rather significant complication rate—as high as 50 percent—including severe infection, possibly requiring amputation.
The use of bulk allografts for cartilage transplantation in nonimmunosuppressed patients should result in a lower complication rate. As of this writing, however, there are too few cases to collect any significant data.
Cell Transplantation. Cell transplantation is another experimental method of replacing lost articular cartilage that has received a great deal of publicity lately. In this procedure, cartilage cells are taken from the patient and then cultured in the laboratory. The cells multiply, producing an abundance of cartilage, and then are reintroduced surgically into the patient. Theoretically, cell transplantation will heal, thus restoring the surface with normal articular cartilage. This experimental procedure was recently reported in the Scandanavian medical literature. The results were promising; however, the patient population was small and primarily had minor defects on either the patellar-femoral or tibia surface. The femoral surface defects appeared to do better than the tibial defects. As exciting as this new procedure may be, it leads many unanswered questions including: How big a defect can be filled? Will it be applicable to all three compartments—the patellar-femoral, the medial femoral-tibial, and the lateral femoral-tibial? Will the patient be able to return to sports? Only time and experience will answer these questions.
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